Femmenessence® MacaLife®
an organic maca supplement formulated specifically for perimenopausal women - those experiencing the hormonal fluctuations that occur in the years leading up to menopause.
Using the proprietary MacaLife® blend of life-stage-specific maca phenotypes, MacaLife® nourishes the body's own hormonal communication network - the HPTAO axis - to support natural estradiol and progesterone regulation rather than introducing exogenous hormones.
the first natural product to have published, double-blind, placebo-controlled human clinical trials demonstrating statistically significant effects on key hormones in perimenopausal women, making it one of the most evidence-backed natural options in the perimenopause category. Benefits
- Clinically proven hormone support - the first natural product with published double-blind, placebo-controlled clinical trials showing statistically significant improvements in both estradiol and progesterone in perimenopausal women, with the placebo crossover design confirming a clear product-related effect
- Broad symptom relief - 74–82% of perimenopausal women in clinical trials reported relief from hot flashes, night sweats, mood fluctuations, sleep changes, and energy shifts within 2 days to 8 weeks, rising to 95% with guidance from the Symphony Medical Team
- Mood, mental clarity, and sleep support - statistically significant improvements in mood, emotional steadiness, sleep quality, and cognitive clarity reported in published clinical trials compared to placebo
- Heart health and healthy body weight - clinical trials showed favourable changes in HDL cholesterol, LDL cholesterol, blood pressure markers, and body weight during the study period
- Hair, skin, and nail health - women in clinical research reported improvements in skin vitality, hair thickness, and nail strength alongside hormonal improvements
- Targets the root cause - not just symptoms - nourishes the HPTAO axis to support the body's own natural hormone production and regulation, addressing both the symptom and the underlying hormonal communication patterns
Ingredients
Per Serve - Serving Size 1 capsule
Organic Gelatinized Maca (Lepidium peruvianum) - 500mg
Hypocotyl Concentrate
MacaLife® (phenotype ratio for perimenopausal women)
Total carbohydrates - 1gm
Other Ingredients: Organic pullulan vegan capsule. Dosage
Take 1 capsule twice a day. Once in the morning before breakfast and 1 in the afternoon 30 minutes before your usual energy dip. Benefits may be noticed within days, though individual response times vary. Precautions
Consult your healthcare professional before use if you are taking prescription medication, have a known medical condition, or have a history of hormone-sensitive conditions. Not for use with tamoxifen or hormone-suppressing medications. Not intended for use during pregnancy - if you are pregnant or breastfeeding, consult your healthcare professional before use. Keep out of reach of children. Store in a cool, dry place away from direct sunlight. More Information
occupies a distinctive position within the Femmenessence range as the only formulation designed specifically for the hormonal volatility of perimenopause - a stage characterised not by declining hormones alone, but by erratic fluctuations in both estradiol and progesterone that can make perimenopause feel particularly unpredictable. It does not contain plant oestrogens, synthetic hormones, or any exogenous hormonal compounds. Instead, it uses Maca-Life® - a proprietary blend of specifically selected maca phenotypes - to nourish the HPTAO axis, the interconnected communication network governing how the body produces, regulates, and balances hormones.
The clinical evidence behind MacaLife® is particularly compelling for a natural product. Published, double-blind, placebo-controlled human clinical trials demonstrated statistically significant improvements in both estradiol and progesterone in perimenopausal women - with the placebo crossover element of the trial showing that women improved on Femmenessence, worsened when switched to placebo, and improved again when switched back. This crossover design provides strong confirmation that the results were product-related rather than attributable to natural disease progression or placebo effect. In addition to the hormonal markers, 74–82% of women reported relief from perimenopausal symptoms within 2 days to 8 weeks, with an average improvement time of 21 days. When supported by Symphony's Medical Team, real-world success rates reached 95%.
Beyond hormones and symptoms, the clinical research also captured broader health improvements relevant to perimenopausal women, including favourable changes in HDL and LDL cholesterol, blood pressure markers, and body weight, as well