Clavulanic acid, lithium salt

or lithium clavulanate is an irreversible inhibitor of β-lactamase class A enzymes, which target β-lactam antibiotics. has been shown operate more efficiently with ceftazidime and amoxicillin antibiotics. Research has also shown an increase in AmpC β-lactamase expression when lithium clavulanate was administered in vitro to Enterobacteriaceae.

potentiates antibiotic effects of penicillin binding protein (PBP) inhibitors by preventing their deconstruction. Effective inhibition of β-lactamases by this compound expand antibiotic duration and lethality, making it useful for susceptibility tests or bacterial selection.